Transdermal Drug Delivery System

Transdermal Drug Delivery System (TDDS)

The transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentration over a prolonged period of time.
Transdermal Drug Delivery System

Advantages of Transdermal Drug Delivery System

  • Reduces dosing frequency and enhancement of patient compliance.
  • It provides the suitability of self-medication.
  • Avoid the first-pass effect.
  • A long duration of action.
  • Ease of termination of drug action, if necessary.
  • No interference with gastric and intestinal fluids.
  • It allows effective use of drugs with short biological half-life.

Disadvantages of Transdermal Drug Delivery System

  • It may cause of skin irritation.
  • It requires a high drug load.
  • Unsuitable if the drug dose is large.
  • Poor diffusion of large molecules.
  • Absorption efficiency varies with different sites of the skin.
Related: Classification of Dosage Forms